Not too long after publishing version 1 of the SmartFlare paper at Science Open, we received a couple of very helpful reviews. We’ve been working on the points made by the reviewers to improve the manuscript for version 2 (coming very shortly!). Below are some thoughts on a couple of the comments and a quick update on some new data in the works.
Update: we have submitted a Letter to PNAS as a response to the paper discussed below. It is currently available as a preprint.
The Mirkin group recently published the latest paper to use Spherical Nucleic Acid (SNA) technology that we’ve come to know and love as Smart/Nano Flares. In an interesting twist, instead of having target oligos bind to the nanoparticle (displacing fluorescent reporter sequences), the reporter sequences are now complimentary to the target oligos, labelling them directly. In theory this allows for dynamic labelled, tracking and quantitation of mRNA in cells.